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    HPLC & Mass Spec 2X Tested
    Same Day Shipping on Orders Before 2PM EST Mon-Sat

    Research use only · Not for human or veterinary use

    α
    ALPHA CARBON LABS
    TB-500 research peptide - high purity lyophilized powder for laboratory research

    10MG

    $80
    3ml Vial
    In Stock
    Bulk Discounts

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    This product is for research purposes only. Not for human consumption.

    Purity: ≥99% (HPLC verified)

    Formulation: Lyophilized powder

    Molecular Formula: C212H350N56O78S

    Molecular Weight: 4963 g/mol

    CAS Number: 77591-33-4

    PubChem CID: 16132341

    TB-500 Molecular Structure

    TB-500

    Tissue Repair Research

    Overview

    The peptide's reported influence on cell migration, angiogenesis, and stem cell differentiation has led to its use in research models studying tissue remodeling, inflammatory responses, and cellular repair mechanisms.

    Mechanism of Action

    TB-500's mechanism of action is primarily related to its interaction with G-actin, the monomeric form of the cytoskeletal protein actin. By sequestering G-actin, it can regulate actin polymerization and cytoskeletal dynamics, which are fundamental to cell motility and structure.

    This actin-binding property has been reported to affect cellular migration. In vitro and in vivo models have shown that TB-500 can influence endothelial cell migration and differentiation, processes associated with angiogenesis (the formation of new blood vessels).

    Studies suggest the peptide can upregulate the expression of certain extracellular matrix proteins and matrix metalloproteinases (MMPs), which are involved in tissue remodeling. It has also been observed to modulate cytokine expression and immune cell function in some models.

    TB-500 has also been studied for its potential to influence stem cell recruitment and differentiation in animal models. Furthermore, some research has described effects on the Akt signaling cascade, which has been linked to cardiomyocyte survival and function in certain injury models.

    Research suggests TB-500 may also influence the expression of genes encoding for proteins such as heat shock proteins and anti-apoptotic factors.

    Research Findings

    Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

    Research Applications

    • Cardiovascular research
    • Wound healing models
    • Musculoskeletal injury models
    • Inflammation and immunomodulation
    • Cell migration and cytoskeletal dynamics
    • Angiogenesis research
    • Nerve injury models
    • Hair follicle stem cell studies
    • Stem cell mobilization and differentiation
    • Corneal injury models
    • Extracellular matrix and tissue remodeling

    Laboratory Handling & Limitations

    This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

    Laboratory Handling

    Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

    Research Limitations

    Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.

    Scientific References

    1. Goldstein, A. L., et al. (2005). Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opinion on Biological Therapy, 5(1), 37-48.
    2. Bock-Marquette, I., et al. (2004). Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 432(7016), 466-472.
    3. Smart, N., et al. (2007). Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 445(7124), 177-182.
    4. Philp, D., et al. (2003). Thymosin β4 promotes matrix metalloproteinase expression during wound healing in diabetic rats. Journal of Cellular Physiology, 196(2), 356-364.
    5. Sosne, G., et al. (2010). Thymosin beta 4: a potential novel therapy for neurotrophic keratopathy, dry eye, and ocular surface diseases. Annals of the New York Academy of Sciences, 1194(1), 199-206.

    Research Use Only

    This product is intended for research purposes only and is not for human consumption, therapeutic use, or diagnostic applications. Please ensure compliance with all applicable regulations and institutional guidelines.