CJC-1295

CJC-1295 no DAC is a synthetic tetrasubstituted 29-amino acid peptide analog of growth hormone-releasing hormone (GHRH). It contains modifications designed to extend its biological half-life and duration of action compared to native GHRH.

Natural GHRH is a 44-amino acid peptide that stimulates growth hormone (GH) secretion from the anterior pituitary gland. It has a short plasma half-life of approximately 6-7 minutes due to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4).

CJC-1295 acts as an agonist of the growth hormone-releasing hormone receptor (GHRHR), a G-protein coupled receptor on somatotroph cells in the anterior pituitary gland.

Intracellular Signaling

Binding of CJC-1295 to GHRHR activates Gs proteins, which in turn stimulate adenylyl cyclase to produce cyclic AMP (cAMP). Elevated cAMP activates protein kinase A (PKA), which phosphorylates transcription factors like cAMP response element-binding protein (CREB). This signaling cascade modulates growth hormone gene expression and secretion.

Downstream Effects

The released growth hormone stimulates the production of insulin-like growth factor 1 (IGF-1), primarily in the liver. IGF-1 is a key mediator of the physiological actions of GH. The GH/IGF-1 axis is known to mediate numerous metabolic and tissue-specific effects. For example, in skeletal muscle models, it is associated with protein synthesis; in adipose tissue models, it is linked to lipolysis; and in bone, it is involved in bone formation.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.