Tesamorelin

This material is provided for controlled laboratory research and analytical characterization only.

Tesamorelin acts as an agonist at the growth hormone-releasing hormone receptor (GHRHR), a G-protein coupled receptor on somatotroph cells in the anterior pituitary gland. Binding to GHRHR activates adenylyl cyclase, leading to an increase in intracellular cyclic AMP (cAMP).

Growth Hormone Release

Elevated cAMP levels activate protein kinase A (PKA), which in turn phosphorylates transcription factors such as CREB (cAMP response element-binding protein). This process upregulates the transcription of the growth hormone gene, resulting in the synthesis and pulsatile secretion of endogenous growth hormone.

By stimulating the pituitary, this mechanism of action functions within the body's existing endocrine feedback systems, which include regulation by IGF-1 and somatostatin.

Effects on Adipose Tissue

Secreted growth hormone, both directly and through stimulation of insulin-like growth factor-1 (IGF-1), has been observed to have metabolic effects. In vitro and in vivo models show these effects include stimulation of lipolysis in adipocytes and promotion of fatty acid oxidation.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.