Semax + Selank Blend

The Semax + Selank Blend is a research formulation containing two peptides. Each vial contains 10mg of Semax and 10mg of Selank as a co-lyophilized powder. This preparation allows investigators to evaluate the combined properties of two neuroactive sequences.

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide, an analog of a fragment of adrenocorticotropic hormone (ACTH 4-10) modified for increased metabolic stability. Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic analog of the peptide tuftsin, modified for a longer half-life in vivo. Both peptides have been investigated in research models for their activities related to cognition, anxiety-like behaviors, and neuroprotective mechanisms.

The blend is intended for laboratory research applications investigating the properties of these two peptides on endpoints related to memory, attention, anxiety-like behavior, and neurochemical signaling.

The blend combines two peptides that are reported to be active within the central nervous system through different mechanisms.

Semax — Melanocortin and Neurotrophic Pathways

In research models, Semax has been observed to modulate the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). It also interacts with melanocortin receptors and has been shown to influence dopaminergic and serotonergic signaling pathways. These activities have been studied in the context of attention, learning, and memory consolidation in research models.

Selank — GABAergic and Immunomodulatory Pathways

In animal studies, Selank has been reported to produce anxiolytic-like effects. This activity has been associated with modulation of GABA receptor expression and serotonergic transmission. These studies also reported observing this activity without sedation or indicators of dependence. Selank has also been observed to influence the expression of certain cytokines and enkephalin-degrading enzymes.

Combined Activity

By combining these two peptides, researchers can investigate multiple pathways concurrently. The preparation is a tool for studying endpoints related to neurotrophic factor signaling, GABAergic modulation, and stress-response in a single model system.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.