Selank

Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and the V.V. Zakusov Research Institute of Pharmacology. The peptide's structure is based on the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), which is derived from the Fc fragment of immunoglobulin G and is involved in immune system processes such as phagocytosis.

Reported Mechanisms of Action

Selank's reported mechanism involves complex modulation of neurotransmitter systems, neurotrophic factors, and immune function rather than direct receptor agonism or antagonism. Research interest in Selank has expanded internationally, with studies exploring its properties in various neuropsychiatric models.

Selank is reported to exert its effects through multiple mechanisms that influence neurotransmitter systems, neurotrophic factors, gene expression, and immune function. Its mechanism is distinct from that of compounds like benzodiazepines, which directly modulate GABA-A receptors, or selective serotonin reuptake inhibitors, which block serotonin transporters.

Immunomodulatory and HPA Axis Effects

Consistent with its structural relationship to tuftsin, Selank exhibits immunomodulatory properties, influencing cytokine production and immune cell function in some experimental settings. The peptide has also been reported to influence the hypothalamic-pituitary-adrenal (HPA) axis, modulating its activation in response to stress in animal models.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.