Rated 4.7/5 by 56 verified customers
100MG
Ships Tomorrow morning if ordered within 20 hrs 31 min.
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This product is for research purposes only. Not for human consumption.
Purity: ≥99% (HPLC verified)
Formulation: Lyophilized powder
Molecular Formula: C21H29N7O14P2
Molecular Weight: 663.43 g/mol
CAS Number: 53-84-9
PubChem CID: 5893
Research Contents
NAD+
Overview
NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in all living cells, essential for fundamental biological processes including energy metabolism, DNA repair, cellular signaling, and gene expression. As we age, NAD+ levels naturally decline, potentially contributing to age-related metabolic dysfunction, mitochondrial decline, and cellular senescence.
The molecule exists in oxidized (NAD+) and reduced (NADH) forms, participating in hundreds of enzymatic reactions, particularly in the electron transport chain where it is crucial for ATP production. Beyond its role in energy metabolism, NAD+ serves as a substrate for sirtuins, PARPs (poly ADP-ribose polymerases), and CD38, enzymes involved in longevity pathways, DNA repair, and immune function.
Research has shown that declining NAD+ levels correlate with various age-related conditions, while restoration of NAD+ through supplementation or precursor administration may support cellular health, mitochondrial function, and metabolic efficiency.
Mechanism of Action
NAD+ functions through several critical pathways in cellular metabolism and regulation. In mitochondria, NAD+ accepts electrons during the breakdown of nutrients, becoming NADH, which then donates these electrons to the electron transport chain to generate ATP, the cell's energy currency. This process is fundamental to cellular respiration and energy production.
Sirtuin Activation
NAD+ serves as a critical substrate for sirtuins (SIRT1-7), a family of NAD+-dependent deacetylases that regulate gene expression, mitochondrial biogenesis, circadian rhythms, and cellular stress responses. When NAD+ levels are sufficient, sirtuins can effectively maintain cellular homeostasis and potentially promote longevity.
DNA Repair and Cellular Protection
NAD+ is consumed by PARPs during DNA repair processes, particularly PARP1 which responds to DNA damage and helps maintain genomic stability. The enzyme CD38, which increases with age and inflammation, is a major consumer of NAD+, converting it to ADP-ribose and nicotinamide. This age-related increase in CD38 activity contributes to declining NAD+ levels.
NAD+ also participates in calcium signaling through conversion to cyclic ADP-ribose (cADPR), influencing numerous cellular processes. The balance between NAD+ synthesis and consumption becomes increasingly important with age, as synthesis pathways may become less efficient while consumption by PARPs and CD38 increases.
Research Findings
Research into NAD+ biology has expanded dramatically over the past two decades, revealing its central role in aging and metabolic health. Foundational studies by David Sinclair and colleagues demonstrated that boosting NAD+ levels in mice through NMN (nicotinamide mononucleotide) supplementation improved mitochondrial function, enhanced exercise capacity, and extended healthspan.
Human Clinical Trials
Human clinical trials have begun to establish safety and preliminary efficacy. A landmark study published in Science showed that NMN supplementation increased NAD+ levels in human participants and improved insulin sensitivity in prediabetic women. Research has also demonstrated that NAD+ boosting can improve cardiovascular function, with studies showing enhanced endothelial function and reduced arterial stiffness in older adults.
Neuroscience and Metabolic Applications
In neuroscience, NAD+ restoration has shown promise in animal models of neurodegenerative diseases, with improvements in cognitive function and neuroprotection observed in Alzheimer's and Parkinson's models. Studies on metabolic health have revealed that NAD+ supplementation can improve mitochondrial function in muscle tissue, enhance fat oxidation, and support healthy glucose metabolism.
NAD+ Precursor Research
Research into different NAD+ precursors (nicotinamide riboside, NMN, nicotinamide, niacin) has helped identify optimal approaches for NAD+ restoration, with NMN and nicotinamide riboside emerging as particularly effective precursors that can elevate NAD+ levels more efficiently than niacin or nicotinamide alone. Investigations into the relationship between NAD+ and circadian rhythms have revealed that NAD+ levels fluctuate throughout the day and that disrupted NAD+ metabolism may contribute to circadian dysfunction.
Research Applications
- Cellular metabolism and energy production research
- Anti-aging and longevity studies
- Mitochondrial function research
- DNA repair mechanism studies
- Neurodegenerative disease research
- Metabolic disorder studies
Safety Profile
NAD+ and its precursors have shown favorable safety profiles in clinical studies. Common administration forms include intravenous infusion, sublingual, or oral supplementation with precursors like NMN or NR. Side effects are generally mild when administered appropriately.
Scientific References
Customer Reviews
Based on 56 reviews
fast shipping and great quality
Ordered this last week and it arrived in two days. The quality is clearly top notch and I’ve been feeling much more energetic lately. highly recommend.
Really impressed with the quality
The customer service here is top notch and you can tell this is high quality. I feel great and will buy again.
Good service and clear labeling
Support was super helpful when I had questions. The labels are very clear and easy to read.
slow delivery
shipping took forever but price was okay.
Solid choice
the bottle arrived quickly and the labels are very easy to read. pricing is fair compared to other shops I have tried previously. overall happy.
Verified and affordable
Solid pricing and the COA gives me peace of mind about the quality. Great value overall.
Always a smooth process
Ordering was simple and I appreciate that the lab tests are so easy to find.
it arrived eventually
the labels are very clear and I like the coa info but shipping took way too long to get here. hopefully it performs well.
Professional Quality
ordering process was a breeze and I appreciate having the COA documentation available. It's high quality for my lab's research projects. arrived quickly too.
Solid product
The labels are very clear and the quality seems top notch.
solid deal
Pricing is great and the COA gave me peace of mind.
Excellent value and secure packaging
Good deal for the price and the bottle was sealed well.
Very happy with this order
Impressive quality and arrived much sooner than I expected.
Solid choice for NAD+
COA checks out and price is fair.
Reliable service as always
Always fast shipping on my reorders.
Solid and reliable every time
I really appreciate the consistent feeling between batches and having the COA documentation available for peace of mind. Great stuff for my routine.
Great value and service
Best price I've found and their team is super helpful.
Back for more
My second order arrived today. Labeling is very clear and easy.
Fast shipping and good packaging
Ordering was very simple and the package arrived carefully wrapped and secure. Very happy.
Lightning fast shipping!
Super high quality and it arrived way faster than I expected.
very professional packaging
securely packed and came with all the paperwork I needed.
Solid product and service
The quality is top notch and I feel great since I started using it. Customer service was super helpful when I had a question about the delivery.
Professional standards
Documentation is very thorough and I appreciate how clear the labels are for my lab. COA was easy to find.
High purity NAD+
ordering was easy and the purity is perfect for my research
Quick and easy!
I was impressed by how easy the website was to use. My package arrived much faster than expected and the quality seems top notch.
Fast arrival
Securely packed and arrived way faster than expected for my ongoing research. Very happy.
My go-to source
The quality is consistently high and always arrives on time. I’ll keep reordering from here.
Simple process and good value
ordering was super easy and the price was way better than my last supplier. everything arrived quickly and i'm happy with how i feel so far.
Always fast delivery
Fast shipping and my second time ordering.
Excellent service and packaging
The package was wrapped really securely when it arrived. I had a quick question about my tracking and the support team responded immediately. Very impressed overall.
Exactly what I needed
Got here extremely fast and everything is labeled very clearly, so it's super easy to use. Great experience from start to finish.
Good Value
solid pricing and the COA checks out for my experiments.
Solid and reliable
Shipping is always quick and the quality stays consistent with every order. I feel pretty good lately, just wish the price was a tiny bit lower.
Solid brand and packaging
The quality is always consistent every time.
Pretty solid overall
shipping was really fast and the product quality seems top notch based on how i feel. wish the bottle was a bit easier to open though.
Shipping was quite slow
Decent product but took forever to arrive.
Solid experience overall
the shipping was quick and I appreciate having the COA right there. Everything arrived exactly as it should have.
Really solid quality
The quality is clearly top notch and I feel great using it. Only docked a star because I wish it was a bit more affordable for my monthly budget.
Top tier value
The pricing here is better than most places I have looked. The labeling is clear and easy to read, which I really appreciate. Great value.
Reliable quality every time
The packaging is always secure and the quality is very consistent with every single order.
Speedy delivery and easy checkout
The ordering process was incredibly smooth and simple. My package arrived way sooner than I expected. I'm really happy with how everything has been going so far.
Feeling great!
Super fast shipping and I feel much better since starting this.
solid choice for research
the value for these is better than most sites. support helped me out with a tracking issue and were super professional.
Really happy with the quality
The purity is top notch and I love that they include the COA. It gives me peace of mind about the quality.
Top tier quality
the coa documentation is spot on. really happy with the purity for my research labs work.
Legit quality stuff
The COA gave me peace of mind. Quality is top notch and I feel great.
Simple and effective
This was my second time ordering and everything went smoothly again. The website is easy to navigate and I am feeling much more energetic lately.
consistent quality
Helpful support and every batch is always very consistent.
Consistent quality every time
Every bottle is identical and the labels make it easy to keep my cabinet organized.
Top notch purity
Pure quality and the paperwork looks great.
Love the consistency
the COAs are always accurate and quality stays consistent.
Transparent company and simple checkout
the website was so easy to navigate and I really appreciate that they include the COA for peace of mind. i feel a lot better since I started using this and I'll definitely be back for more soon.
Consistent results and quick delivery
the products are always consistent every time i order and it arrives way faster than i expect. i'm really happy with this supplier and the shipping speed has been top notch for my research.
Proper COA documentation and solid purity
The NAD+ arrived quickly and the third party testing provided on the site gave me a lot of confidence in the purity for my project. Only docking a star because it was out of stock for a while before I could order.
Great shipping speed and verified purity
The NAD+ arrived within three days and the packaging was very secure. Lab results are consistent with the provided COA, making this a great value for my current study.
Reliable source for high quality research materials
The ordering process was simple and the NAD+ arrived quickly. Testing shows high purity and it's been a great addition to my current research project.
Research Use Only
This product is intended for research purposes only and is not for human consumption, therapeutic use, or diagnostic applications. Please ensure compliance with all applicable regulations and institutional guidelines.