Melanotan-I (MT-1)

Melanotan I (MT-1) is a synthetic tridecapeptide analog of the naturally occurring peptide hormone alpha-melanocyte stimulating hormone (α-MSH). It is also known by the non-proprietary name afamelanotide.

MT-1 is an agonist of the melanocortin-1 receptor (MC1R), a G-protein coupled receptor expressed on melanocytes.

Extended Half-Life

Amino acid substitutions in the MT-1 peptide sequence confer resistance to enzymatic degradation, which extends its half-life in comparison to the endogenous α-MSH peptide.

Melanogenesis Pathway

Binding of MT-1 to MC1R on melanocytes initiates a signaling cascade that increases intracellular cAMP levels. This leads to the activation of protein kinase A and phosphorylation of the CREB transcription factor. This process upregulates MITF expression, which in turn increases the expression of melanogenic enzymes like tyrosinase, TRP-1, and TRP-2.

Resulting Melanin Production

The described pathway leads to an increase in melanin synthesis. Melanin is a pigment known to absorb UV radiation, neutralize reactive oxygen species, and dissipate UV energy as heat.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.