MK-677 (Ibutamoren)

MK-677, also known as Ibutamoren or by its research designation L-163,191, is an orally active, non-peptide growth hormone (GH) secretagogue. It is a small molecule peptidomimetic designed to be stable in gastric acid and intestinally absorbed, unlike some peptide-based GH secretagogues which are susceptible to gastrointestinal degradation.

MK-677 is a selective agonist of the growth hormone secretagogue receptor type 1a (GHS-R1a), a Gq-coupled G-protein coupled receptor which is the endogenous receptor for ghrelin.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.