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10MG
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This product is for research purposes only. Not for human consumption.
Purity: >98% (HPLC verified)
Formulation: Lyophilized powder
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.2 g/mol
CAS Number: 121062-08-6
PubChem CID: 16132341
Research Contents
Melanotan-II (MT-2)
Overview
Melanotan-II (MT-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH), developed at the University of Arizona in the 1980s. It was designed to produce tanning without UV exposure by stimulating melanin production in the skin. The peptide has the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, incorporating a lactam bridge that enhances metabolic stability and receptor selectivity.
Melanotan-II acts as a non-selective agonist at melanocortin receptors MC1R through MC5R, which mediate diverse physiological functions including pigmentation, sexual function, appetite regulation, and inflammation. The peptide's effects on multiple receptor subtypes account for its range of biological activities observed in research settings.
Mechanism of Action
Melanotan-II binds to melanocortin receptors, particularly MC1R on melanocytes in the skin. Activation of MC1R stimulates adenylyl cyclase through G-protein coupling, increasing intracellular cAMP levels. This activates protein kinase A and the transcription factor CREB, leading to increased expression of tyrosinase and other melanin synthesis enzymes. The result is enhanced production of eumelanin, the brown-black pigment responsible for tanning.
Beyond MC1R, Melanotan-II's activity at MC3R and MC4R in the hypothalamus influences appetite and sexual function pathways. MC4R activation in particular has been associated with pro-erectile effects through central nervous system mechanisms involving oxytocin and dopamine pathways. This non-selectivity accounts for the peptide's observed effects beyond pigmentation.
Research Findings
Research on Melanotan-II has explored both its melanogenic and sexual function effects. Early clinical studies at the University of Arizona demonstrated dose-dependent increases in skin pigmentation without UV exposure, along with side effects including nausea and facial flushing at higher doses.
Pigmentation Studies
Clinical trials showed that subcutaneous Melanotan-II produced measurable increases in melanin density and skin darkening. The tanning effect was most pronounced in fair-skinned individuals and persisted for weeks after treatment cessation. Research suggested potential photoprotective benefits through increased eumelanin, though this has not been established as a therapeutic indication.
Sexual Function Research
Studies investigated Melanotan-II for erectile dysfunction, leading to the development of the derivative drug bremelanotide (PT-141), which specifically targets sexual function through MC4R. Clinical research demonstrated pro-erectile effects in both psychogenic and organic erectile dysfunction populations.
Research Applications
- Melanogenesis and pigmentation research
- Melanocortin receptor pharmacology
- UV-independent tanning mechanisms
- Sexual function and libido studies
- MC1R/MC4R signaling pathway research
- Photoprotection research
- Appetite regulation studies
Safety Profile
Melanotan-II has not been approved for therapeutic use by regulatory agencies. Common side effects observed in clinical research include nausea, facial flushing, fatigue, and appetite suppression. Concerns exist regarding effects on existing moles and potential melanoma risk, though causality has not been established. Cardiovascular effects through MC3R/MC4R activation are theoretically possible. Products from unregulated sources may vary significantly in purity and composition. Long-term safety data in humans is limited.
Scientific References
Customer Reviews
Based on 39 reviews
Always fast and reliable
Every order has been consistent and arrived quickly. Definitely my go-to spot for MT2.
Very satisfied
Fast shipping and high quality product.
Great experience
Clear labels and their service is really top notch.
Consistent quality and clear labels
Labels are very clear so I never mix them up. Just placed my third reorder because the quality is always consistent. highly recommend this.
Clear labels and great service
labels are easy to read. reordering now.
Great value and transparency
The pricing is fair and I really appreciate seeing the lab testing papers on the site. Everything feels very high quality.
Always my go-to choice
Third time ordering. Delivery was incredibly fast as usual. The quality is always consistent and I couldn't be happier with how well it works for me.
Always reliable quality
consistent every time and easy ordering
Very professional service
The support team answered all my questions and the labels are very easy to read.
Always consistent and fast
I've reordered from here three times now and the quality is always top notch. Shipping is super fast too, usually arrives in just a couple days.
Really happy with this
Great results and the price is fair.
Fast shipping and solid quality
Arrived in just two days and the quality is top notch. It is exactly what I needed for my routine.
Quality stuff
Good purity and priced very well.
Always consistent
Arrived so fast and it's the same great quality every time.
Consistent and reliable service
I have ordered several times and it is always the same high quality. Ordering is simple and my package arrived exactly when expected. Very satisfied customer.
Super fast shipping!
The ordering process was so easy and I received my package in just two days.
Consistency is key
Shipping is always super fast and i love that the quality is consistent every single time I order this stuff. Highly recommend.
Always a good experience
I love how clear the labels are. This was my third time ordering and everything arrived quickly like usual. Very happy.
Shipping could be faster
i am happy with the quality of this product but it took forever to arrive. the tracking update was stuck for four days straight.
Fast delivery and great packaging
Super fast shipping and everything was packed very securely. Really happy with the service provided.
Fast as usual
Another easy reorder. It arrived in two days and the quality is always spot on.
Good stuff as always
Every order has been consistent so far and the quality is definitely there. Happy with it.
Reliable and consistent
Packaged well and the quality is always the same every time.
Best deal online
Good price and arrived really fast.
Impressive quality
shipped fast and it works great!
Excellent!
Top quality and came way faster than I expected. Great stuff.
Quick arrival
Super fast shipping and the labels are very easy to read.
Easy process and great value
Ordering process was super simple and you really can't beat these prices for the value. Everything arrived on time and I am very happy with it.
Decent experience overall
Great documentation but shipping was slow.
Shipping was slow
COAs were provided but my second order took forever to arrive. decent for my research nevertheless, but the shipping wait was annoying.
Top tier quality
COAs are consistent every single order.
Consistent labels
the label is always easy to read and looks consistent.
Affordable and good support
good price and service was helpful.
Solid choice
the purity seems spot on and it was packaged really well so everything arrived safely. only taking off a star because it took a few extra days.
Arrival was slow
Shipping took way longer than expected this time, but the product quality is still consistent.
Stellar shipping speed
Securely wrapped and arrived at my door within two days.
Great experience overall
The customer service team was very helpful and everything was labeled clearly. Fast shipping and the product is high quality.
Top quality stuff
Always consistent and the packaging is great.
Excellent value
Super fast delivery and the pricing is better than other sites I have tried. Very pleased.
Research Use Only
This product is intended for research purposes only and is not for human consumption, therapeutic use, or diagnostic applications. Please ensure compliance with all applicable regulations and institutional guidelines.