Mazdutide

Mazdutide, also identified in the literature as IBI362 and LY3305677, is a synthetic dual agonist of the glucagon-like peptide-1 (GLP-1) receptor and the glucagon receptor. It belongs to the class of multi-receptor incretin analogues and is structurally based on oxyntomodulin, a naturally occurring gut hormone that activates both receptors.

Position Among Incretin Analogues

Research on multi-receptor incretin analogues has proceeded along several parallel lines, including GLP-1/GIP dual agonists such as tirzepatide, GLP-1/glucagon dual agonists such as mazdutide and survodutide, and triple agonists such as retatrutide. Because these classes activate different receptor combinations, comparative research is an active area, and findings from one class should not be assumed to transfer to another.

Mazdutide activates two G protein-coupled receptors with different tissue distributions and different downstream effects. These can be understood as two mechanisms operating in parallel.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.