Ipamorelin

Ipamorelin is a pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2. It is described as a selective growth hormone secretagogue (GHS) that stimulates growth hormone (GH) release from the pituitary gland. In some studies, it has been observed to do so without significantly affecting cortisol, prolactin, or thyroid-stimulating hormone levels.

This selectivity profile distinguishes it from some earlier-generation GH secretagogues. The peptide is a ghrelin mimetic, acting by binding to the growth hormone secretagogue receptor (GHS-R1a). This binding can trigger a pulsatile release of GH that is reported to mimic endogenous secretion patterns.

Ipamorelin has been investigated for its potential role in laboratory models of muscle and bone biology, metabolism, and age-related changes in GH secretion.

Ipamorelin functions by selectively binding to and activating the growth hormone secretagogue receptor (GHS-R1a), which is expressed in the pituitary gland and various peripheral tissues. Upon receptor activation, Ipamorelin can stimulate the pulsatile release of growth hormone (GH) from somatotroph cells in the anterior pituitary. Some reports suggest this release pattern maintains the natural ultradian rhythm of GH secretion.

Ipamorelin has demonstrated high selectivity for stimulating GH release in certain experimental models, without concurrently stimulating ACTH/cortisol, prolactin, or thyroid hormones. This distinguishes its activity from that of some other growth hormone secretagogues.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

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Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.