GHRP-2

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide with the sequence D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH2. It is a growth hormone secretagogue that functions by binding to and activating the ghrelin receptor (GHS-R1a).

Mechanism of Action

GHRP-2 acts through the ghrelin receptor to amplify GH pulsatility, a mechanism distinct from that of growth hormone releasing hormone (GHRH), which acts through the GHRH receptor. In laboratory models, concurrent activation of both pathways has been observed to result in GH release greater than the individual responses.

GHRP-2 functions as a growth hormone secretagogue by binding to and activating the growth hormone secretagogue receptor type 1a (GHS-R1a), which is also the receptor for the endogenous hormone ghrelin.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.