Dihexa

Dihexa, also known by its chemical designation N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is a peptidomimetic compound developed at Washington State University. It was investigated for its potential to penetrate the blood-brain barrier and act as a potentiator of hepatocyte growth factor (HGF) and its receptor, c-Met.

Dihexa is reported to act through activation of the HGF/c-Met signaling system. The c-Met receptor is a receptor tyrosine kinase that, upon ligand binding, undergoes dimerization and autophosphorylation, initiating downstream signaling pathways including PI3K/Akt, MAPK/ERK, and STAT.

Published nonclinical literature relevant to this material's molecular targets and experimental models is listed below for independent review. Findings involving other preparations or experimental systems should not be attributed to this research material.

This material is supplied solely for in vitro and other nonclinical laboratory research. It is not for human or veterinary use, consumption, administration, therapeutic use, or diagnostic use.

Laboratory Handling

Handle only in an appropriately equipped laboratory using applicable institutional procedures, personal protective equipment, and the storage conditions shown for the material. The purchaser is responsible for study design, handling controls, disposal, and regulatory compliance.

Research Limitations

Published observations involving other preparations, experimental systems, or study populations do not establish the identity, performance, or suitability of this research material for any particular experiment.